Just read a tough word in Isaiah 43:22, "Yet you did not call upon me, O Jacob, but you have been weary of me, O Israel." We all know weariness; applying that to God, our sin looks even more deplorable!
All sin is becoming weary or tired of God. A good question to ask ourselves is simply this, "Where and when am I weary of God?"
Not "if"...since we all sin. Why do we grow weary? From this perspective, we have a different way to approach our prayer time, Scripture study, worship, service, and life in general....what do you do to not grow weary in a day and throughout the day? In the words of George Mueller, our duty evey morning and all day is to make sure we are "happy [i.e. overflowing in joy] in God", otherwise, we are useless at the breakfast table or anywhere else.